Using Marine Natural Products to Discover a Protease that Catalyzes Peptide Macrocyclization of Diverse Substrates

Peptide Macrocyclization Inspired by Non-Ribosomal Imine Natural Products

A thermodynamic approach to peptide macrocyclization inspired by the cyclization of non-ribosomal peptide aldehydes is presented. The method provides access to structurally diverse macrocycles by exploiting the reactivity of transient macrocyclic peptide imines toward inter- and intramolecular nucleophiles. Reactions are performed in aqueous media, in the absence of side chain protecting groups...

marine microbial natural products

A remodelled protease that cleaves phosphotyrosine substrates.

Proteases are the largest family of enzymes in the human genome and play central roles in a wide range of physiological processes.1 To carry out these diverse functions, proteolytic enzymes have evolved highly tuned substrate specificities that allow them to degrade specific cellular proteins in response to appropriate signals. For many proteases, this specificity is encoded by the amino acid s...

Marine natural products.

Covering: 2016. Previous review: Nat. Prod. Rep., 2017, 34, 235-294This review covers the literature published in 2016 for marine natural products (MNPs), with 757 citations (643 for the period January to December 2016) referring to compounds isolated from marine microorganisms and phytoplankton, green, brown and red algae, sponges, cnidarians, bryozoans, molluscs, tunicates, echinoderms, mangr...

Bioactive marine natural products

Bioactive marine natural products can be defined as biologically active products, both secondary metabolites as well as enzymes, lipids and heteropolysaccharides derived from marine sources. Marine natural products have been found to be an important source of drugs and drug leads. These natural products are secondary metabolites and enhance survival fitness and may serve as chemical weapons use...